【文献解读】生物囊泡作为超声/磁共振分子造影剂
摘要
本视频介绍了生物囊泡最近的研究进展。生物气囊（GV）自2014年被发现可以进行超声成像以来，在磁共振成像、基因调控下的分子成像、微生物成像方面都取得了成功，有望取代绿色荧光蛋白（GFP），作为在体内的新一代细菌甚至是细胞的示踪工具。未来的方向包括GV在载体中的分子成像以及声学报告基因在哺乳动物的表达和成像。挑战在于血管内循环时间短以及蛋白外壳存在免疫原性，除此之外，声学报告基因从细菌到细胞转换困难。
参考文献
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